Jack L. Arbiser, MD, PhD

Thomas J. Lawley Professor of Dermatology

Department of Dermatology

Member

Winship Cancer Institute

Staff Physician

Division of Dermatology, Atlanta VA Medical Center

Office: Woodruff Memorial Research Building: Office 5309 and Labs 5337-5339

Phone: 404-727-5063

Fax: 404-727-5897

Email: jarbise@emory.edu

Additional Contact Information

Mailing Address:

Emory University: Department of Dermatology

1525 Clifton Road
Suite 100

Atlanta , NY 30322

Education

  • MD/PhD, Harvard Medical School, Boston, MA
  • Internship, Harvard Medical School/Beth Israel Hospital, Boston, MA
  • Dermatology Residency, Harvard Medical School/Massachusetts General Hospital , Boston, MA
  • Howard Hughes Postdoctoral Fellowship, Laboratory of Judah Fiolkman, MD, Harvard Medical School
  • Certifications: American Board of Dermatology

Research

  • Vascular birthmarks of children and angiosarcomas
  • Benign neoplasms in tuberous sclerosis 
  • Pathogenesis of malignant melanoma 

My laboratory has a long history of development of small molecules as antiangiogenic and antitumor therapies. We have both discovered natural products and synthesized novel small molecules. I obtained a combined BS/MS degree in the laboratory of Dr. Dennis Liotta and then spent time in the laboratory of Dr. Raymond Schinazi on the development and evaluation of antiviral drugs. This led to a collaboration that developed Emtriva, which is currently taken by more than 90% of HIV positive patients in the US. I obtained a MD/PhD degree at Harvard Medical School and then a Howard Hughes Fellowship in the laboratory of Dr. Judah Folkman following dermatology training at Harvard. My laboratory discovered the antiangiogenic and in vivo antitumor properties of honokiol, and has synthesized honokiol analogs. In addition, my lab has synthesized Imipramine Blue, a novel NADPH oxidase inhibitor with systemic availability and antitumor efficacy. The Arbiser laboratory has recently pioneered a novel synthesis of solenopsin and solenopsin analogs, and has demonstrated that these analogs may act as ceramide analogs in demonstrating tumor suppressive activity. Finally, we have discovered and patented the antitumor properties of palladium complexes, including Tris DBA Palladium, with the intent to license them for clinical development.

Select Honors and Awards:

  • Senior Research Award, Department of Dermatology, Emory University, 2013 
  • Albert E. Levy Award for the Senior Investigator, Emory University, 2007

Society and Professional Memberships:

  • American Association for Cancer Research 
  • The Society for Investigative Dermatology 
  • American Academy of Dermatology 
  • Tuberous Sclerosis Alliance 
  • The Dermatology Foundation 
  • The Sturge-Weber Foundation

Publications